Macrophage scavenger receptors: Role in adhesion, uptake and migration

Dawn Bowdish. Department of Pathology & Molecular Medicine. McMaster University

26 November 2009 at 10:30

Location: JHE 326H

Macrophages are tissue-resident white blood cells that are essential for detection of pathogens, clearance of modified host products and recognition of foreign bodies. Macrophages recognize both host and foreign ligands via surface expressed receptors. The result of this recognition may be a pro-inflammatory response, phagocytosis, or differentiation & adhesion. Although macrophage responses are essential for host defence and tissue homeostasis, they can also be detrimental when the macrophage is unable to clear foreign particles such as implants or environmental and synthetic particles. The scavenger receptors are macrophage receptors that have the unusual capacity of recognizing modified self proteins, pathogens and foreign particulates. We aim to determine how these receptors transmit signals to the cell and how this signaling affects macrophage adhesion, phagocytosis & endocytosis (uptake) and migration.

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