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Office: JHE A409
Voice: +1 (905) 525 9140 extension 24701 email: email@example.com
- B.Sc. (Eng), Engineering Chemistry, Queen’s University (2001)
- Ph.D., Chemical Engineering, McMaster University (2006)
- Post-Doctoral Fellow, Langer Lab, Massachusetts Institute of Technology (2006-2008)
The Hoare lab works at the interface of polymer science, physical chemistry, and biology, aiming to design novel materials with “smart” properties precisely tuned to the environment and application in which the material is to be used. Our main expertise lies in the rational design of “smart” hydrogel-based materials on different length scales (i.e. bulk hydrogels, microgels, and nanogels) based on a fundamental understanding of the structure-property relationships in such materials. To achieve this understanding, we apply both the analytical tools of physical chemistry and the mathematical modeling tools of chemical engineering to predict microstructures prior to synthesis and then characterize (and optimize) the realized microstructures for specific applications. While most of our target applications lie within biomedical engineering (drug delivery, cell encapsulation, biomedical devices, biosensors, and tissue engineering), we also apply our engineered hydrogels in food, nutriceutical delivery, and environmental applications.
For more information about Dr. Hoare’s research, visit his lab webpage at http://hoarelab.mcmaster.ca
Hoare, T.; Langer, R.; Zurakowski, D.; Kohane, D.S. “Rheological blends for drug delivery. I: Characterization in vitro” Journal of Biomedical Materials Research A, in press.
Hoare, T.; Bellas, E.; Zurakowski, D.; Kohane, D.S. “Rheological blends for drug delivery. II: Prolongation of nerve blockade, biocompatibility, and in vivo-in vitro correlations” Journal of Biomedical Materials Research A, in press.
Hoare, T.; Pelton, R. “Characterizing Charge and Crosslinker Distributions in Polyelectrolyte Microgels”. Current Opinion in Colloid and Interface Science, in press.
Hoare, T.R.; Kohane, D.S. “Hydrogels in Drug Delivery: Progress and Challenges”. Polymer 2008, 49, 1993-2007.
Hoare, T.; Pelton, R. “Charge-Switching, Amphoteric Glucose-Responsive Microgels with Physiological Swelling Activity”. Biomacromolecules, 2008, 9, 733-740.
Hoare, T.; Pelton, R. “The Impact of Microgel Morphologies on Functional Microgel-Drug Interactions”. Langmuir2008, 24, 1005-1012.
Hoare, T.; Pelton, R. “Functionalized Microgel Swelling: Comparing Theory and Experiment”. Journal of Physical Chemistry B, 2007 111, 11895-11906.
Hoare, T.; Pelton, R. “Calorimetric Analysis of Thermal Phase Transitions in Functionalized Microgels”. Journal of Physical Chemistry B 2007, 111, 1334-1342.
Hoare, T.; Pelton, R. “Engineering Glucose Swelling Responses in Poly(N-isopropylacrylamide)-Based Microgels”. Macromolecules 2007, 40, 670-678.
Hoare, T.; McLean, D. “Kinetic Prediction of Functional Group Distributions in Microgels”. Journal of Physical Chemistry B 2006, 110, 20327-20336.
Hoare, T.; McLean, D. “Multi-Component Kinetic Modeling for Controlling Local Compositions in Thermosensitive Polymers”. Macromolecular Theory and Simulations 2006 15, 619-632.
Hoare, T.; Pelton, R. “Dimensionless Plot Analysis: A New Way to Analyze Functional Group Distributions in Microgels”. Journal of Colloid and Interface Science. 2006, 303, 109-116.
Hoare, T.; Pelton, R. “Titrametric Characterization of pH-Induced Phase Transitions in Functionalized Microgels”.Langmuir 2006, 22, 7342-7350.
Hoare, T.; Pelton, R. “Electrophoresis of Functionalized Microgels: Morphological Insights”. Polymer 2005, 46, 1139-1150.
Hoare, T.; Pelton, R. “Highly pH and Temperature-Responsive Microgels Functionalized with Vinylacetic Acid”. Macromolecules 2004, 37, 2544-2550.
Selected Patent Applications
Hoare, T.; Kohane, D.; Fenn, A.; Langer, R. “Externally-Triggered Thermosensitive Membranes”, United States Provisional Patent Application filed July, 2008.
Simons, M.; Hoare, T.; Kohane, D.; Langer, R. “Membrane Permeating Ear Drops and Methods of
Treatment of Ear Diseases Using Same”. U.S. Patent Application No 61/054,339
McLean, D.; Hoare, T.; Jones, K. “Novel Vaccine Adjuvants: Polymer Microgels”. US Patent Application 61/040,350; Canadian Patent Application 2,627,903, filed March, 2008.
Hoare, T.; Pelton, R. “Glucose-Responsive Microgels”. United States Provisional Patent Application
No. 60/667,114; April 1, 2005