Dr. Heather Sheardown
Professor, Canada Research Chair in Ophthalmic Biomaterials and Drug Delivery
Department of Chemical Engineering
1280 Main Street West,
Hamilton, ON, L8S 4L7, Canada
Driving directions and map

Office: JHE 124A
Voice: +1 (905) 525 9140 extension 24794
email: sheardow@mcmaster.ca

biomaterials, tissue engineering, mathematical modeling of physiologic processes, ophthalmic drug delivery.
Education
  • B.Eng. McMaster University (1989)
  • Ph.D. University of Toronto (1995)

About 

 

Dr. Sheardown holds a Tier 1 Canada Research Chair Ophthalmic Biomaterials and Drug Delivery Systems. She is an expert in drug delivery, contact lens materials, IOLs, polymer chemistry, and bioengineering in the ophthalmic space.  

 

Active Research Initiatives

 

C20/20 - ORF 

 

The Biomedical Engineering and Advanced Manufacturing (BEAM) project  

 

Past Research Initiatives

 

20/20 Network

 

Research Interests 

 

1) Drug delivery - Anterior Eye

 

2) Drug delivery - Posterior Eye

 

3) Contact Lens

 

4) IOLs 

 

5) In Vivo Ocular Testing 

 

A Selection of Recent Publications 

 

Rastergari B, Zenali S, Sheardown H, Karbelaei-Heidari HR.  The enzyme-sensitive release of prodigiosin grafted β-cyclodextrin and chitosan magnetic nanoparticles as an anticancer drug delivery system: synthesis, characterization and cytotoxicity studies.  Eur J Pharm Biopharm.  Submitted 2016. 

 

Xu F, Sheardown H, Hoare T.  Reactive electrospinning of degradable poly (oligoethylene glycol methacrylate) based nanofibrous hydrogel networks.  Chem Commun 52: 1451-1454 (2016).

 

 Princz MA, Sask KN, Brash JL, Sheardown H.  Pre-activated heparinized crosslinked collagen matrices as improved blood contacting materials.  J Biomater Applications Submitted 2016.

 

Brunette I, Roberts CJ, Vidal F, Harissi-Dagher M, Lachaine J, Sheardown H, Durr GM, Proulx S, Griffith M.  Alternatives to native eye bank tissue for corneal stromal replacement.  Invited review.  Progress in Retinal and Eye Research In Press 2016.

 

 Zhang J, Muirhead B, Dodd M, Liu L, Mangiacotte N, Xu F, Hoare TR, Sheardown H.  An injectable hydrogel prepared using a PEG/Vitamin E copolymer facilitating aqueous driven gelation.  Biomacromolecules  17: 3648-3658 (2016)

 

Jamard M, Hoare TR, Sheardown H.  Nanogels of methylcellulose hydrophobized with N-tert-butylacrylamide for ocular drug delivery.  J Trans Drug Delivery Res 6: 648-659 (2016).

 

Fawcett AS, Liu L, Prosperi-Porta G, Korogiannaki M, Sheardown H.  Natural polymers for ocular drug delivery.  Journal of Biomedical Engineering and Medical Devices.  Submitted 2016.

 

Fitzpatrick SD, Mazumder J, Baek D, Zhao X, Wang H, Fitzpatrick L, Boyd S, Sheardown H.  Optically transparent thermally gelling drug delivery scaffold for minimally invasive posterior segment drug delivery. Acta Biomaterialia Submitted 2016.

 

Lasowski F, Sheardown H.  Atropine and roscovitine release from model silicone hydrogels.  Optom Vis Sci. 93: 404-411 (2016)

 

Deng X, Korogiannaki M, Rastegari B, Zhang J, Chen M, Fu Q, Sheardown H, Filipe C, Hoare T.  ‘Click’ Chemistry-Tethered Hyaluronic Acid-Based Contact Lens Coatings Improve Lens Wettability and Lower Protein Adsorption ACS Applied Materials and Interfaces.  8: 22064-22073 (2016).

 

Prosperi-Porta G, Kedzior S, Muirhead B, Sheardown H.  Phenylboronic acid based polymeric micelles for mucoadhesive anterior segment ocular drug delivery Biomacromolecules  17:1449-1457 (2016).

 

Korogiannaki M, Guidi G, Jones L, Sheardown H.  Timolol maleate release from hyaluronic acid-containing model silicone hydrogel contact lens materials  J Biomater Appl 30:361-376 (2015)

 

Prosperi-Porta G, Muirhead B, Sheardown H.  Tunable release of ophthalmic therapeutics from injectable, resorbable, thermoresponsive copolymer scaffolds.  J Biomed Mater Res B doi: 10.1002/jbm.b.33501

Sheikholeslami P, Baek DS, Muirhead B, Wang H, Zhao H, Sivakumaran D Boyd S, Sheardown H, Hoare TR. Hydrophobically modified poly(vinyl pyrrolidone) as a physically associative, shear responsive ophthalmic hydrogel Exp Eye Res 137: 18-31 (2015).

 

Xu F, Sheardown H, Hoare TR.  Reactive Electrospinning of Degradable Poly(oligoethylene glycol methacrylate)-Based Nanofibrous Hydrogel Networks.  Chem Communications. 52: 1451-1454 (2016).

 

Rambarran T, Gonzaga F, Brook MA, Lasowksi F, Sheardown H.  Amphiphilic  elastomers from metal free click crosslinking of PEG-grafted silicone surfactants.  J Polym Sci Part A: Polym Chem 53:1082-1093 (2015).